The teratogenic risk of trimethoprim-sulfonamides: a population based case-control study.

@article{Czeizel2001TheTR,
  title={The teratogenic risk of trimethoprim-sulfonamides: a population based case-control study.},
  author={Andrew Endre Czeizel and Magda Rockenbauer and Henrik Toft S\orensen and J\orn Olsen},
  journal={Reproductive toxicology},
  year={2001},
  volume={15 6},
  pages={637-46}
}
OBJECTIVE To study human teratogenic potential of two trimethoprim-sulfonamide combinations: trimethoprim-sulfamethoxazole (cotrimoxazole) and trimethoprim-sulfamethazine during pregnancy. These agents have antifolate effects and other antifolate agents can induce multiple congenital abnormalities, neural-tube defects, cardiovascular, and other malformations in animal experiments and in humans. DESIGN Pair analysis of cases with congenital abnormalities and matched healthy controls in the… CONTINUE READING

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