The teratogenic potencies of valproic acid derivatives and their effects on biological end-points are related to changes in histone deacetylase and Erk1/2 activities.

@article{Gotfryd2011TheTP,
  title={The teratogenic potencies of valproic acid derivatives and their effects on biological end-points are related to changes in histone deacetylase and Erk1/2 activities.},
  author={Kamil Gotfryd and Maria Benn Hansen and Akira Kawa and Ursula Ellerbeck and Heinz Nau and Vladimir Berezin and Elisabeth Bock and Peter Schledermann Walmod},
  journal={Basic & clinical pharmacology & toxicology},
  year={2011},
  volume={109 3},
  pages={
          164-74
        }
}
Valproic acid (VPA) is a known teratogen. In the present study, the effects of VPA and seven VPA derivatives with different teratogenic potencies (isobutyl-, 5-methyl-, ethyl-, propyl-, butyl-, pentyl- and hexyl-4-yn-VPA) were investigated in L929 cells in vitro. Evaluated end-points included changes in cell proliferation, growth, cell cycle distribution, morphology, speed, glycogen synthase kinase-3β (GSK-3β) and Erk1/2 phosphorylation, and histone H3 acetylation. Changes in proliferation… CONTINUE READING
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