The temporal fate of drugs in decomposing porcine tissue.

  title={The temporal fate of drugs in decomposing porcine tissue.},
  author={John F Wyman and Dorothy E Dean and Rachel Yinger and Amber C Simmons and David Brobst and Michael Bissell and Fernando Silveira and Nancy Kelly and Robert Shott and Joseph Ohr and Rick Howard and Bradley Lewis},
  journal={Journal of forensic sciences},
  volume={56 3},
Drug levels in decomposed individuals are difficult to interpret. Concentrations of 16 drugs were monitored in tissues (blood, brain, liver, kidney, muscle, and soil) from decomposing pigs for 1 week. Pigs were divided into groups (n = 5) with each group receiving four drugs. Drug cocktails were prepared from pharmaceutical formulations. Intracardiac pentobarbital sacrifice was 4 h after dosing, with tissue collection at 4, 24, 48, 96, and 168 h postdosing. Samples were frozen until assay… CONTINUE READING

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