The temporal dynamics of vertebrate limb development, teratogenesis and evolution.

@article{Zeller2010TheTD,
  title={The temporal dynamics of vertebrate limb development, teratogenesis and evolution.},
  author={Rolf Zeller},
  journal={Current opinion in genetics & development},
  year={2010},
  volume={20 4},
  pages={384-90}
}
Recent genetic and functional analysis of vertebrate limb development begins to reveal how the functions of particular genes and regulatory hierarchies can drastically change over time. The temporal and spatial interplay of the two instructive signalling centres are part of a larger signalling system that orchestrates limb bud morphogenesis in a rather self-regulatory manner. It appears that mesenchymal cells are specified early and subsequently, the progenitors for the different skeletal… CONTINUE READING