The temporal basis of angiogenesis

@article{Bentley2017TheTB,
  title={The temporal basis of angiogenesis},
  author={Katie Bentley and Shilpa Chakravartula},
  journal={Philosophical Transactions of the Royal Society B: Biological Sciences},
  year={2017},
  volume={372}
}
The process of new blood vessel growth (angiogenesis) is highly dynamic, involving complex coordination of multiple cell types. Though the process must carefully unfold over time to generate functional, well-adapted branching networks, we seldom hear about the time-based properties of angiogenesis, despite timing being central to other areas of biology. Here, we present a novel, time-based formulation of endothelial cell behaviour during angiogenesis and discuss a flurry of our recent… 
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References

SHOWING 1-10 OF 101 REFERENCES
Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement
TLDR
A time-lapse imaging and computer-assisted analysis system is established that quantitatively characterizes behaviors in sprouting angiogenesis and provides new insights into the individual and collective EC movements driving angiogenic morphogenesis.
Temporal modulation of collective cell behavior controls vascular network topology
TLDR
This work provides the first example of a host tissue-derived signal (Semaphorin3E-Plexin-D1) that accelerates tip cell selection rate, yielding a dense network.
Time to Decide? Dynamical Analysis Predicts Partial Tip/Stalk Patterning States Arise during Angiogenesis
TLDR
Overall, this study demonstrates that different factors can be used to modulate the speed of tip/stalk decisions, opening up new opportunities and challenges for future biological experiments and therapeutic targeting to manipulate vascular network topology.
VEGFRs and Notch: a dynamic collaboration in vascular patterning.
TLDR
It is anticipated that the study of mosaic vascular beds of genetically modified ECs in dynamic interactions with wild-type ECs will provide a powerful tool for the investigation of the molecular control and cellular mechanisms of EC specification.
Can Active Perception Generate Bistability? Heterogeneous Collective Dynamics and Vascular Patterning
TLDR
It is proposed here that the traditional “decide then move” perspective of cell behavior in angiogenesis may miss a key temporal regulator as it is too slow to account for the rapid, adaptive assignment of heterogeneous cell states.
Flt-1 (VEGFR-1) coordinates discrete stages of blood vessel formation.
TLDR
The results show that VEGF-A signalling has stage-specific effects on vascular morphogenesis, and that understanding these effects on dynamic stages of angiogenesis and how they integrate to expand a vessel network may suggest new therapeutic strategies.
Robustness in angiogenesis: notch and BMP shaping waves.
TLDR
How Delta-like ligand 4 (DLL4)-Notch and BMP effector interplay may drive nonsynchronized oscillatory gene expression in ECs essential for setting sharp tip-stalk cell boundaries while sustaining a dynamic pool of nonsprouting ECs is focused on.
Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion
TLDR
This work shows that the expression of the Notch ligand Dll4 fluctuates in individual endothelial cells within sprouting vessels in the mouse retina in vivo and in correlation with dynamic cell movement in mouse embryonic stem cell-derived sprouting assays, and proposes that this sensitive phase transition in the behaviour of the Vegf-Dll4/Notch feedback loop underlies the morphogen function of Vegfa in vascular patterning.
Agent-based model of angiogenesis simulates capillary sprout initiation in multicellular networks.
TLDR
An agent-based model of sprouting angiogenesis is constructed to evaluate endothelial cell sprout initiation frequency and location, and it is compared to a Monte Carlo model, revealing that purely stochastic simulations could not generate sprout locations as accurately as the rule-informed agent- based model.
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