The temperature-dependent modulation of an inhibitory circuit in hippocampal slices as revealed by a population spike recording is mediated by extracellular adenosine.

@article{Fujii2001TheTM,
  title={The temperature-dependent modulation of an inhibitory circuit in hippocampal slices as revealed by a population spike recording is mediated by extracellular adenosine.},
  author={Satoshi Fujii and Yoichiro Kuroda and Jicheng Li and Kiyotaka Ito and Koichi Kaneko and Hiroshi Sasaki and Hiroshi Kato},
  journal={The Japanese journal of physiology},
  year={2001},
  volume={51 5},
  pages={545-54}
}
We examined the effects of temperature on excitatory synaptic transmission and the recurrent inhibitory loop in CA1 neurons in guinea pig hippocampal slices. Increasing the temperature of the perfusing medium from 30 to 49 degrees C resulted in attenuation of both the amplitude of the synaptically evoked CA1 population spikes and the paired-pulse inhibition (PPI) of the spikes. A bath application of 2 microM picrotoxin, a gamma-aminobutyric acid receptor antagonist, did not affect the amplitude… CONTINUE READING
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