The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.

@article{Zhou2011TheTI,
  title={The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.},
  author={Xiao Zhen Zhou and Pengyu Huang and Rong Shi and Tae Ho Lee and Gina H Lu and Zhi-hong Zhang and Roderick Bronson and Kun Lu},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 4},
  pages={
          1266-82
        }
}
Telomerase is activated in most human cancers and is critical for cancer cell growth. However, little is known about the significance of telomerase activation in chromosome instability and cancer initiation. The gene encoding the potent endogenous telomerase inhibitor PinX1 (PIN2/TRF1-interacting, telomerase inhibitor 1) is located at human chromosome 8p23, a region frequently exhibiting heterozygosity in many common human cancers, but the function or functions of PinX1 in development and… CONTINUE READING

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