The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes.

@article{Ross1996TheTG,
  title={The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes.},
  author={Ted M Ross and Sherrie M Pettiford and Patrick L. Green},
  journal={Journal of virology},
  year={1996},
  volume={70 8},
  pages={5194-202}
}
The mechanism of human T-cell leukemia virus (HTLV)-mediated transformation and induction of malignancy is unknown; however, several studies have implicated the viral gene product, Tax. Conclusive evidence for the role of Tax in the HTLV malignant process has been impeded by the inability to mutate tax in the context of an infectious virus and dissociate viral replication from cellular transformation. To circumvent this problem we constructed a mutant of HTLV type 2 (HTLV-2) that replicates by… CONTINUE READING
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