The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases.

@article{Vermeiren2018TheTP,
  title={The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases.},
  author={C{\'e}line Vermeiren and Philippe Motte and Delphine Viot and Georges Mairet-Coello and Jean-Philippe Courade and Martin Citron and Jo{\"e}l Mercier and Jonas Hannestad and Michel Gillard},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2018},
  volume={33 2},
  pages={273-281}
}
BACKGROUND Lilly/Avid's AV-1451 is one of the most advanced tau PET tracers in the clinic. Although results obtained in Alzheimer's disease patients are compelling, discrimination of tracer uptake in healthy individuals and patients with supranuclear palsy (PSP) is less clear as there is substantial overlap of signal in multiple brain regions. Moreover, accurate quantification of [18 F]AV-1451 uptake in Alzheimer's disease may not be possible. OBJECTIVES The aim of the present study was to… CONTINUE READING
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