The tau gene A0 allele and progressive supranuclear palsy.

  title={The tau gene A0 allele and progressive supranuclear palsy.},
  author={J. Hoenicka and Mar P{\'e}rez and Jordi P{\'e}rez-Tur and Alexander Barabash and Montserrat Godoy and L{\'i}dice Vidal and R. Astarloa and Jes{\'u}s {\'A}vila and Torbjoern Nygaard and Justo Garc{\'i}a de Y{\'e}benes},
  volume={53 6},
BACKGROUND Recent studies have shown an association between a polymorphic tandem repeat allele, located in intron 9, of the tau gene and progressive supranuclear palsy (PSP). OBJECTIVE To investigate this tau polymorphism in individuals with a clinical diagnosis of sporadic or familial PSP as well as in cases confirmed by pathology. METHODS We analyzed the frequency of tau intronic polymorphism, the presence of linkage in two families with multiple cases of PSP, the splicing of exon 10, and… CONTINUE READING

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