The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy.

@article{Ostojic2004TheTR,
  title={The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy.},
  author={Jovanka Ostojic and Christina Elfgren and Ulla Passant and Karin Svedberg Nilsson and Lars L Gustafson and Lars Lannfelt and Susanne Froelich Fabre},
  journal={Dementia and geriatric cognitive disorders},
  year={2004},
  volume={17 4},
  pages={298-301}
}
Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are two frequent causes of dementia that share both clinical and neuropathological features. Common to both disorders are the neurofibrillary tangles consisting of aggregations of hyperphosphorylated tau protein. Recently, a number of different pathogenic mutations in the tau gene have been identified in families with FTD and parkinsonism linked to chromosome 17 (FTDP-17). In the present study, a Swedish family with presenile… CONTINUE READING

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