The target of daptomycin is absent from Escherichia coli and other gram-negative pathogens.


Antistaphylococcal agents commonly lack activity against Gram-negative bacteria like Escherichia coli owing to the permeability barrier presented by the outer membrane and/or the action of efflux transporters. When these intrinsic resistance mechanisms are artificially compromised, such agents almost invariably demonstrate antibacterial activity against… (More)
DOI: 10.1128/AAC.02005-12

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