The target cell response to cytokines governs the autoreactive T cell repertoire in the pancreas of NOD mice

@article{Hultcrantz2008TheTC,
  title={The target cell response to cytokines governs the autoreactive T cell repertoire in the pancreas of NOD mice},
  author={Monica Hultcrantz and Stella Jacobson and Natasha J. Hill and Pere Santamaria and Malin Flodstr{\"o}m-Tullberg},
  journal={Diabetologia},
  year={2008},
  volume={52},
  pages={299-305}
}
The pancreatic beta cell response to cytokines is crucial for the development of type 1 diabetes in the NOD mouse. For example, beta cell production of suppressor of cytokine signalling-1 (SOCS-1) protects against diabetes. This finding and other recent studies indicated that cytokine-stressed beta cells might contribute to disease progression by affecting the pancreatic lymphocyte infiltrate. The aim of this study was to provide insight into how the beta cell influences the pancreas… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 41 references

SOCS proteins, cytokine signalling and immune regulation

Nature Reviews Immunology • 2007
View 11 Excerpts
Highly Influenced

Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.

Proceedings of the National Academy of Sciences of the United States of America • 2001
View 5 Excerpts
Highly Influenced

Islet inflammation and T cell autoreactivity in pancreasdraining lymph nodes during recent onset type 1 diabetes

F Dotta, V Bonato, F Vendrame
2008

Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients.

Proceedings of the National Academy of Sciences of the United States of America • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…