The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice.

@article{Cryan2005TheTS,
  title={The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice.},
  author={John F Cryan and C{\'e}dric Mombereau and Annick Vassout},
  journal={Neuroscience and biobehavioral reviews},
  year={2005},
  volume={29 4-5},
  pages={571-625}
}
Since its introduction almost 20 years ago, the tail suspension test has become one of the most widely used models for assessing antidepressant-like activity in mice. The test is based on the fact that animals subjected to the short-term, inescapable stress of being suspended by their tail, will develop an immobile posture. Various antidepressant medications reverse the immobility and promote the occurrence of escape-related behaviour. This review focuses on the utility this test as part of a… CONTINUE READING
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