The tag SNP for HLA-DRB1*1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: cost-effective high-throughput detection by real-time PCR.

@article{Zivkovic2009TheTS,
  title={The tag SNP for HLA-DRB1*1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: cost-effective high-throughput detection by real-time PCR.},
  author={Maja Zivkovic and Aleksandra Stankovi{\'c} and Evica Din{\vc}i{\'c} and Milan Popovi{\'c} and Smiljana Popovi{\'c} and Ranko Rai{\vc}evi{\'c} and Dragan Alavantic},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2009},
  volume={406 1-2},
  pages={27-30}
}
BACKGROUND Recently a high-resolution HLA and SNP map was defined and the analysis provided informative tag SNPs that capture much of the common variation in the MHC region. This concept enables detection of smaller number of SNPs, making it "surrogate" markers for haplotype associated with certain disease. The SNP rs3135388 was proposed as a tagging SNP for DRB1*1501/DQB10602 alleles, associated with MS. The aim of the study was to investigate the HLA rs3135388 genotypes in association with MS… CONTINUE READING

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HLA-DRB1 andmultiple sclerosis inMalta

DeanG, YeoTW, A Goris
Neurology • 2008

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