The t(4;22)(q12;q11) in atypical chronic myeloid leukaemia fuses BCR to PDGFRA.

Abstract

Chronic myeloid leukaemia (CML) is characterized by the presence of the BCR-ABL fusion gene, usually in association with the t(9;22)(q34;q11) translocation. We report here the identification and cloning of a rare variant translocation, t(4;22)(q12;q11), in two patients with a CML-like myeloproliferative disease (MPD). RT-PCR indicated that both patients… (More)

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@article{Baxter2002TheTI, title={The t(4;22)(q12;q11) in atypical chronic myeloid leukaemia fuses BCR to PDGFRA.}, author={E. Joanna Baxter and Andreas Hochhaus and Pascual Bolufer and Andreas Reiter and Jos{\'e} Mar{\'i}a Fern{\'a}ndez and Leonor Senent and Jose V Cervera and Federico Moscard{\'o} and Miguel {\'A}ngel Sanz and N. C. Cross}, journal={Human molecular genetics}, year={2002}, volume={11 12}, pages={1391-7} }