The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance.

Abstract

A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behavior was compared to a group characterized by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5%) and smoldering… (More)
DOI: 10.3324/haematol.2009.016329

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@article{Ross2010TheTI, title={The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance.}, author={Fiona M. Ross and Laura Chiecchio and Gianpaolo Dagrada and Rebecca K M Protheroe and David M Stockley and Christine J Harrison and N. C. Cross and Alex J Szubert and Mark Trehane Drayson and Gareth J Morgan}, journal={Haematologica}, year={2010}, volume={95 7}, pages={1221-5} }