The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor.

@article{McNeil1999TheTC,
  title={The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor.},
  author={Sandra M. McNeil and Chan Zeng and Kimberly Stacy Harrington and Sheldon Hiebert and Jane B Lian and Andre J van Wijnen and Gary S Stein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 26},
  pages={
          14882-7
        }
}
Targeting of gene regulatory factors to specific intranuclear sites may be critical for the accurate control of gene expression. The acute myelogenous leukemia 8;21 (AML1/ETO) fusion protein is encoded by a rearranged gene created by the ETO chromosomal translocation. This protein lacks the nuclear matrix-targeting signal that directs the AML1 protein to appropriate gene regulatory sites within the nucleus. Here we report that substitution of the chromosome 8-derived ETO protein for the… CONTINUE READING
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