The t(6;9) associated DEK/CAN fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation

@article{Oancea2010TheTA,
  title={The t(6;9) associated DEK/CAN fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation},
  author={Claudia Oancea and Brigitte Ruester and Reinhard Henschler and Elena Puccetti and Martin Ruthardt},
  journal={Leukemia},
  year={2010},
  volume={24},
  pages={1910-1919}
}
The t(6;9)-positive acute myeloid leukemia (AML) is classified as a separate clinical entity because of its early onset and poor prognosis. The hallmark of t(6;9) AML is the expression of the DEK/CAN fusion protein. The leukemogenic potential of DEK/CAN has been called into question, because it was shown to be unable to block the differentiation of… CONTINUE READING