The systemic reaction during inflammation: the acute-phase proteins.

  title={The systemic reaction during inflammation: the acute-phase proteins.},
  author={Fabrizio Ceciliani and Alessia Giordano and Valentina Spagnolo},
  journal={Protein and peptide letters},
  volume={9 3},
The acute-phase response consists in a large number of behavioural, physiologic, biochemical, and nutritional changes involving many organ systems distant from the site, or sites, of inflammation. One of the most investigated, but still not well understood, characteristic of the acute phase is the up-regulation, or down- regulation, of many plasma proteins, known as the acute-phase proteins. The changes in the concentrations of these positive acute-phase proteins and negative acute-phase… CONTINUE READING