The systemic delivery of siRNAs by a cell penetrating peptide, low molecular weight protamine.

@article{Choi2010TheSD,
  title={The systemic delivery of siRNAs by a cell penetrating peptide, low molecular weight protamine.},
  author={Young-Suk Choi and Jue Yeon Lee and Jin Sook Suh and Young-Min Kwon and Seung-Jin Lee and Jun-Key Chung and Dong-Soo Lee and Victor C Yang and C Chung and Yoon-Jeong Park},
  journal={Biomaterials},
  year={2010},
  volume={31 6},
  pages={1429-43}
}
Small interfering RNAs (siRNAs), used for specific down-regulation of targeted genes, have garnered considerable interest as an attractive new class of drugs for broad clinical applications. The polyanionic charges carried by these siRNAs, however, restrain cellular uptake and consequently limit effects on gene regulation. Herein the authors describe a peptide/siRNA complex containing the cell penetrating peptide derived from natural protamine, termed low molecular weight protamine (LMWP), for… CONTINUE READING