The systemic bioavailability of buprenorphine by various routes of administration.

@article{Brewster1981TheSB,
  title={The systemic bioavailability of buprenorphine by various routes of administration.},
  author={David K. McGookin Stephen A. Brewster and Michael J. Humphrey and M A Mcleavy},
  journal={The Journal of pharmacy and pharmacology},
  year={1981},
  volume={33 8},
  pages={500-6}
}
The systemic bioavailability of buprenorphine has been studied in female rats following single doses (200 microgram kg-1) administered by one of six different routes. Relative to the 100% bioavailability from the intraarterial route the mean bioavailabilities were intravenous, 98%; intrarectal, 54%; intrahepatoportal, 49%; sublingual, 13%; and intraduodenal, 9.7%. Area under the curve analysis of buprenorphine concentrations in blood showed the relative fractions of drug extracted (first pass… CONTINUE READING