The systemic availability of buprenorphine administered by nasal spray

  title={The systemic availability of buprenorphine administered by nasal spray},
  author={J. Eriksen and Niels H. Jensen and M. Kamp-Jensen and Helle Bjarn{\o} and P. Friis and D. Brewster},
  journal={Journal of Pharmacy and Pharmacology},
Abstract— The kinetics and systemic bioavailability of intranasally administered buprenorphine have been investigated in 9 healthy volunteers in an intranasal/intravenous cross‐over study. Each subject received a nominal 0·3 mg dose of buprenorphine intranasally followed one week later by a matched dose intravenously. For the intranasal administration mean tmax and mean Cmax were 30·6 min and 1·77 ng mL−1, respectively. Mean intranasal bioavailability was 48·2 ± 8·3% (mean ± s.e.m.) of the… Expand
Intranasal absorption of buprenorphine--in vivo bioavailability study in sheep.
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  • Drugs Made in Germany
  • 1983
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