The systemic availability of buprenorphine administered by nasal spray

  title={The systemic availability of buprenorphine administered by nasal spray},
  author={J{\o}rgen Eriksen and Niels H. Jensen and Michael Kamp-Jensen and Helle Bjarn{\o} and Poul Friis and David Brewster},
  journal={Journal of Pharmacy and Pharmacology},
Abstract— The kinetics and systemic bioavailability of intranasally administered buprenorphine have been investigated in 9 healthy volunteers in an intranasal/intravenous cross‐over study. Each subject received a nominal 0·3 mg dose of buprenorphine intranasally followed one week later by a matched dose intravenously. For the intranasal administration mean tmax and mean Cmax were 30·6 min and 1·77 ng mL−1, respectively. Mean intranasal bioavailability was 48·2 ± 8·3% (mean ± s.e.m.) of the… 
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