The systemic availability of buprenorphine administered by nasal spray

@article{Eriksen1989TheSA,
  title={The systemic availability of buprenorphine administered by nasal spray},
  author={J{\o}rgen Eriksen and Niels H. Jensen and Michael Kamp-Jensen and Helle Bjarn{\o} and Poul Friis and David Brewster},
  journal={Journal of Pharmacy and Pharmacology},
  year={1989},
  volume={41}
}
Abstract— The kinetics and systemic bioavailability of intranasally administered buprenorphine have been investigated in 9 healthy volunteers in an intranasal/intravenous cross‐over study. Each subject received a nominal 0·3 mg dose of buprenorphine intranasally followed one week later by a matched dose intravenously. For the intranasal administration mean tmax and mean Cmax were 30·6 min and 1·77 ng mL−1, respectively. Mean intranasal bioavailability was 48·2 ± 8·3% (mean ± s.e.m.) of the… 
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References

SHOWING 1-9 OF 9 REFERENCES
Nasal absorption of naloxone and buprenorphine in rats
Sublingual buprenorphine used postoperatively: clinical observations and preliminary pharmacokinetic analysis.
TLDR
It is suggested that this route may be particularly appropriate for highly lipophilic drugs like buprenorphine, as it caused a significant fall in the postoperatively elevated plasma glucose, and prevented any further rise in plasma cortisol.
Buprenorphine kinetics
TLDR
Comparison of the kinetics of the same patient, awake and anesthetized, showed that the clearance was significantly lower in the anESThetized state, so that peaks are obtained in 2 to 5 min, and in 10 min the resulting levels are the same as for the intravenous and intramuscular routes.
Radioimmunoassay of Buprenorphine with Iodine Label: Analysis of Buprenorphine and Metabolites in Human Plasma
TLDR
An extraction procedure coupled with radioimmunoassay which allows the sensitive and specific measurement of buprenorphine using an iodinated bupenorphine derivative and the measurement of extracted and unextracted samples using two different antisera allowed investigation of the metabolism of buPrenorphines.
Sublingual buprenorphine used postoperatively: ten hour plasma drug concentration analysis.
TLDR
Plasma drug concentrations after sublingual buprenorphine were significantly higher than those in the placebo group by 1 h and remained significantly higher over the succeeding nine hours.
Transnasal systemic medications : fundamentals, developmental concepts, and biomedical assessments
Vergleichende Studie zwischen einem Zerstauberspray und einem Mikrodosierspray beziiglich der freigesetzten Dosen und der Haufigkeitsverteilung der gebildeten Tropfchen
  • Pharm . Ind
  • 1982
Investigation of the dosing accuracy of atomizer pumps compared to the accuracy of aerosol dosing values
  • Drugs Made in Germany
  • 1983
Investigation of the dosing accuracy of atomizer pumps compared to the accuracy of aerosol dosing
  • values. Drugs Made in Germany
  • 1983