The systemic administration of gamma interferon inhibits collagen synthesis and acute inflammation in a murine skin wounding model.

@article{Granstein1989TheSA,
  title={The systemic administration of gamma interferon inhibits collagen synthesis and acute inflammation in a murine skin wounding model.},
  author={Richard D Granstein and M{\'a}ria De{\'a}k and Steven L. Jacques and Randall J Margolis and Thomas J Flotte and Darrel Whitaker and F H Long and Edward P. Amento},
  journal={The Journal of investigative dermatology},
  year={1989},
  volume={93 1},
  pages={18-27}
}
The ability of gamma interferon (IFN-gamma) to affect cutaneous collagen synthesis in vivo was examined in a murine wounding model. Reproducible areas of full-thickness skin necrosis were produced by argon laser radiation. Mice received recombinant murine IFN-gamma (rMuIFN-gamma) (8.7 X 10(3) units/hr) over 14 d via osmotic pumps implanted subcutaneously or intraperitoneally. At 14 and 21 d after wounding, there was less fibrous tissue in healing scars of treated animals as determined by light… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

The role of interferon-gamma in murine pneumococcal pneumonia.

The Journal of infectious diseases • 2002
View 1 Excerpt

Similar Papers

Loading similar papers…