The system N transporter SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptors.

@article{Hamdani2012TheSN,
  title={The system N transporter SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptors.},
  author={El Hassan Hamdani and Marius Gudbrandsen and Mona Bj\orkmo and Farrukh Abbas Chaudhry},
  journal={Glia},
  year={2012},
  volume={60 11},
  pages={1671-83}
}
Activation of NMDA receptor requires two co-agonists, glutamate and glycine. Despite its intrinsic role in brain functions molecular mechanisms involved in glutamate replenishment and identification of the origin of glycine have eluded characterization. We have performed direct measurements of glycine flux by SN2 (Slc38a5; also known as SNAT5), executed extensive electrophysiological characterization as well as implemented ratiometric analyses to show that SN2 transport resembles SN1 in… CONTINUE READING

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