The synthetic rate of muscle triglyceride but not phospholipid is increased in obese rabbits.

@article{Zhang2009TheSR,
  title={The synthetic rate of muscle triglyceride but not phospholipid is increased in obese rabbits.},
  author={Xiao-jun Zhang and David L. Chinkes and Zhanpin Wu and David N . Herndon and Robert R. Wolfe},
  journal={Metabolism: clinical and experimental},
  year={2009},
  volume={58 11},
  pages={1649-56}
}
Fat is a major energy source for skeletal muscle, and disruption of normal trafficking of fatty acids in muscle is linked to insulin resistance. We quantified muscle triglyceride (TG) and phospholipid (PL) synthesis in lean and obese rabbits by means of l-[U-(13)C(16)]palmitate infusion. Intramyocellular palmitoyl-coenzyme A was used as the precursor for rates of TG and PL synthesis, which were compared with the rates calculated using plasma nonesterified palmitate as the precursor. The muscle… CONTINUE READING

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Isotopic tracers in metabolic research: principle and practice of kinetic analysis

  • RR Wolfe, DL Chinkes
  • 2004
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