The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met as a novel adjuvant for DNA vaccine.

@article{Lee2005TheSP,
  title={The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met as a novel adjuvant for DNA vaccine.},
  author={Chang Geun Lee and So Young Choi and S Park and Ki Seok Park and Sung Ho Ryu and Young Chul Sung},
  journal={Vaccine},
  year={2005},
  volume={23 38},
  pages={4703-10}
}
Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm) is a synthetic peptide known to activate human neutrophils, monocytes and dendritic cells, resulting in the enhancement of superoxide generation, bactericidal activity, chemotactic migration and survival. In this study, we demonstrated that WKYMVm enhanced the surface expression of CD80, but not that of CD40, CD86 and MHC class II, on mouse bone marrow-derived dendritic cells which is one of the essential costimulatory signals for the induction of immune… CONTINUE READING

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