The synthetic neuroactive steroid SGE-516 reduces status epilepticus and neuronal cell death in a rat model of soman intoxication

Abstract

Organophosphorus nerve agents (OPNAs) are irreversible inhibitors of acetylcholinesterase that pose a serious threat to public health because of their use as chemical weapons. Exposure to high doses of OPNAs can dramatically potentiate cholinergic synaptic activity and cause status epilepticus (SE). Current standard of care for OPNA exposure involves… (More)
DOI: 10.1016/j.yebeh.2016.12.024

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@article{Althaus2017TheSN, title={The synthetic neuroactive steroid SGE-516 reduces status epilepticus and neuronal cell death in a rat model of soman intoxication}, author={Alison L. Althaus and Hilary S. McCarren and Aymen Alqazzaz and Cecelia Jackson and John H. McDonough and Carl D Smith and Ethan Hoffman and Rebecca S. Hammond and Albert J. Robichaud and James Doherty}, journal={Epilepsy & Behavior}, year={2017}, volume={68}, pages={22-30} }