The synthetic gestagen Levonorgestrel disrupts sexual development in Xenopus laevis by affecting gene expression of pituitary gonadotropins and gonadal steroidogenic enzymes.

@article{Lorenz2011TheSG,
  title={The synthetic gestagen Levonorgestrel disrupts sexual development in Xenopus laevis by affecting gene expression of pituitary gonadotropins and gonadal steroidogenic enzymes.},
  author={Claudia Lorenz and Valeska Contardo-Jara and Achim Trubiroha and Angela K Krueger and Viola Viehmann and Claudia Wiegand and Stephan Pflugmacher and Gunnar N{\"u}tzmann and I. C. Lutz and Werner Kloas},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2011},
  volume={124 2},
  pages={311-9}
}
In the present study, Xenopus laevis tadpoles were chronically exposed to four concentrations of the synthetic gestagen Levonorgestrel (LNG; 10(-11), 10(-10), 10(-9), and 10(-8)M) starting at Nieuwkoop and Faber (NF) stage 48 until completion of metamorphosis. At NF 58 and 66, brain-pituitary and gonad samples were taken for gene expression analyses of gonadotropins and gonadal steroidogenic enzymes. Exposure to 10(-9) and 10(-8)M LNG until NF 58 repressed messenger RNA (mRNA) expression of… CONTINUE READING
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