The synthetic cannabinoid WIN 55212-2 differentially modulates thigmotaxis but not spatial learning in adolescent and adult animals.

@article{Acheson2011TheSC,
  title={The synthetic cannabinoid WIN 55212-2 differentially modulates thigmotaxis but not spatial learning in adolescent and adult animals.},
  author={Shawn K. Acheson and Nicole Leigh Tadisch Moore and Cynthia M. Kuhn and Wilkie A. Wilson and H Scott Swartzwelder},
  journal={Neuroscience letters},
  year={2011},
  volume={487 3},
  pages={411-4}
}
Unlike Δ(9)-THC, the synthetic compound WIN 55212-2 (WIN) is a full agonist of endogenous cannabinoid receptors. Previous work has shown Δ(9)-THC to affect adolescent and adult animals differently on numerous behavioral measures of spatial memory, anxiety, and locomotor activity. However, far less is known about the developmental and neurobehavioral effects of WIN. To address this, we assessed the effect of WIN (1mg/kg) on spatial learning in adolescent and adult rats using the Morris water… CONTINUE READING

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