The synthesis of triterpenic amides on the basis of 2,3-seco-1-cyano-19β,28-epoxy-18α-oleane-3-oic acid

@article{Tolmacheva2010TheSO,
  title={The synthesis of triterpenic amides on the basis of 2,3-seco-1-cyano-19$\beta$,28-epoxy-18$\alpha$-oleane-3-oic acid},
  author={I. A. Tolmacheva and E. V. Igosheva and V. V. Grishko and O. Zhukova and G. K. Gerasimova},
  journal={Russian Journal of Bioorganic Chemistry},
  year={2010},
  volume={36},
  pages={377-382}
}
Novel 2,3-seco-triterpenic amides were prepared by the interaction of the chloride of 1-cyano-19β,28-epoxy-18α-oleane-3-oic acid with primary amines and synthetic and biogenic amino acids. A cytotoxic triterpenic conjugate with a residue of the ethyl ester of β-alanine was found among the synthesized nitrogen-containing derivatives. Treatment with this conjugate in a concentration of 100 μM resulted in the 45.5% survival of melanoma cells in the medium. 
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