The synthesis of poly-L-arginine hydrobromide and copolymers of L-arginine and other amino acids.

@article{Hayakawa1969TheSO,
  title={The synthesis of poly-L-arginine hydrobromide and copolymers of L-arginine and other amino acids.},
  author={Tadao Hayakawa and Yoshiyuki Kondo and H Yamamoto and Yukiko Murakami},
  journal={Bulletin of the Chemical Society of Japan},
  year={1969},
  volume={42 2},
  pages={
          479-82
        }
}
Pure crystalline Nω,ω′-dicarbobenzyloxy-L-arginine N-carboxyanhydride hydrochloride was obtained from Nα,ω,ω′-tricarbobenzyloxy-L-arginine and thionyl chloride. It was polymerized to poly-Nω,ω′-dicarbobenzyloxy-L-arginine. This polymer was converted to poly-Nω-carbobenzyloxy-L-arginine by treating it with alcoholic potassium hydroxide; also, both carbobenzyloxy groups of the protected polymer were completely removed into poly-L-arginine by treating them with hydrogen bromide in glacial acetic… Expand
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TLDR
This new method for the removal of the nitro group was applied successfully in the synthesis of poly- L-arginine hydrochloride from poly-L-nitro arginine, which had been prepared by the polymerization of N-carbothiophenyl-L -nitroarginines in dimethylsulfoxide at 120°C for 14 hr. Expand
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