The synthesis of new oxindoles as analogs of natural product 3,3$^\prime $-bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of G6PD and 6PGD

@article{Bayindir2018TheSO,
  title={The synthesis of new oxindoles as analogs of natural product 3,3\$^\prime \$-bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of G6PD and 6PGD},
  author={Sinan Bayindir and Adnan Ayna and Yusuf Temel and Mehmet Çiftçi},
  journal={Turkish Journal of Chemistry},
  year={2018},
  volume={42},
  pages={332-345}
}
Natural and synthetic derivatives that contain an indole core are being used in medical treatments and technological processes. Therefore, the development of new synthetic methods for the synthesis of indole derivatives is very popular. In this study, new oxindoles with reaction of 4,7-dihydro-1$H$-indole (2) and isatin (4) were synthesized as analogs of natural product 3,3$^\prime $-bis(indolyl)oxindole. The biological properties of the compounds obtained during this study were also studied… 

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References

SHOWING 1-2 OF 2 REFERENCES

The PyMOL Molecular Graphics System

Anticancer Agents Med

  • Chem. 2014,
  • 2014