The synthesis of a new type of anthracene DNA intercalator.

Abstract

A new type of DNA intercalator based on anthracene 3 was synthesized. Preliminary binding studies show high affinity of this probe to CT-DNA. Higher binding constant of this compound (4.0 x 10(4) M-1) as compared with that known for 9-aminomethylanthracene, is caused presumably by enhanced electrostatic interaction.

Cite this paper

@article{Ostaszewski1998TheSO, title={The synthesis of a new type of anthracene DNA intercalator.}, author={Ryszard Ostaszewski and Ewa Wilczyńska and Marian Wolszczak}, journal={Bioorganic & medicinal chemistry letters}, year={1998}, volume={8 21}, pages={2995-6} }