The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.

@article{HornilloAraujo2007TheSA,
  title={The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.},
  author={Ana R Hornillo-Araujo and Adam J M Burrell and Miren Karmele Aiertza and Takayuki Shibata and David M Hammond and Dolor{\`e}s Edmont and Harry Adams and G. P. Margison and David M. Williams},
  journal={Nucleosides, nucleotides & nucleic acids},
  year={2007},
  volume={26 8-9},
  pages={1099-102}
}
The syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of O(6)-methylguanine and S(6)-methylthioguanine are described. The crystal structures and pK(a) values of these analogues are reported. In a standard substrate assay with the human repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.