The synthesis and pharmacological evaluation of adamantane-derived indoles: cannabimimetic drugs of abuse.

@article{Banister2013TheSA,
  title={The synthesis and pharmacological evaluation of adamantane-derived indoles: cannabimimetic drugs of abuse.},
  author={Samuel D Banister and Shane M. Wilkinson and Mitchell Longworth and Jordyn Stuart and Nadine Apetz and Katrina English and Lance Brooker and Catrin Goebel and David E. Hibbs and Michelle Glass and Mark Connor and Iain S McGregor and Michael Kassiou},
  journal={ACS chemical neuroscience},
  year={2013},
  volume={4 7},
  pages={1081-92}
}
Two novel adamantane derivatives, adamantan-1-yl(1-pentyl-1H-indol-3-yl)methanone (AB-001) and N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide (SDB-001), were recently identified as cannabimimetic indoles of abuse. Conflicting anecdotal reports of the psychoactivity of AB-001 in humans, and a complete dearth of information about the bioactivity of SDB-001, prompted the preparation of AB-001, SDB-001, and several analogues intended to explore preliminary structure-activity relationships within… CONTINUE READING
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