The synthesis and activities of fatty acid-conjugated CpG oligodeoxynucleotide

Abstract

SUMMARY Several kinds of fatty acid-conjugated CpG oligodeoxynucleotides(ODN) were synthesized via click reaction between azido-modified fatty acid and alkyne-modified CpG ODNs. The immunological activities of fatty acidconjugated CpG ODNs were examined and compared with unmodified CpG ODNs. INTRODUCTION DNA oligodeoxynucleotide(ODN) sequences that include… (More)

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