The syngeneic mixed leukocyte reaction: an autoreactive self-renewing cellular network for mature T lymphocytes.

  • G A dos-Reis
  • Published 1986 in
    Brazilian journal of medical and biological…


The functional properties of responding T lymphocytes and the nature of the antigenic stimulus in the guinea pig Syngeneic Mixed Leukocyte Reaction (SMLR) are reviewed. The evidence presented here indicates that the SMLR is a polyclonal T cell proliferative response of several distinct antigen-specific clones by virtue of their reactivity with self Ia (I… (More)