The synergistic effects of combining cocaine and heroin ("speedball") using a progressive-ratio schedule of drug reinforcement.

@article{Duvauchelle1998TheSE,
  title={The synergistic effects of combining cocaine and heroin ("speedball") using a progressive-ratio schedule of drug reinforcement.},
  author={Christine L. Duvauchelle and T Sapoznik and Conan Kornetsky},
  journal={Pharmacology, biochemistry, and behavior},
  year={1998},
  volume={61 3},
  pages={297-302}
}
The relative reinforcing value of cocaine/heroin combination ("speedball") was compared in the rat using a progressive-ratio (PR) reinforcement schedule. The initial training for all rats was a combined dose of 18 microg/kg/inj of heroin (H) plus 300 microg/kg/inj of cocaine (C). Break points for the training dose and individual component doses were determined for half and double the training dose. Of the three doses of each treatment, only C yielded the expected monotonic increase in break… CONTINUE READING

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