The synergistic effects of betulin with acyclovir against herpes simplex viruses.

@article{Gong2004TheSE,
  title={The synergistic effects of betulin with acyclovir against herpes simplex viruses.},
  author={Yunhao Gong and K. Mathan Raj and Carolyn A Luscombe and Izabelle Gadawski and Teresa Tam and Jianhua Chu and David Gibson and Robert 0. Carlson and Stephen L. Sacks},
  journal={Antiviral research},
  year={2004},
  volume={64 2},
  pages={127-30}
}
Betulin, a pentacyclic triterpenoid, was isolated from the bark of Betula papyrifera. The antiviral efficacies of betulin on herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) were evaluated using viral plaque reduction assays on Vero cells. The results indicate that betulin is active against both HSV-1 and HSV-2 infections with the 50% effective concentrations (EC(50)) of 0.40 and 4.15 microg/ml, respectively. The cytotoxicity of betulin was examined on Vero cells using a neutral red… CONTINUE READING
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