The synergistic effects of DNA-targeted chemotherapeutics and histone deacetylase inhibitors as therapeutic strategies for cancer treatment.

@article{Stiborov2012TheSE,
  title={The synergistic effects of DNA-targeted chemotherapeutics and histone deacetylase inhibitors as therapeutic strategies for cancer treatment.},
  author={Marie Stiborov{\'a} and Tomas Eckschlager and Jitka Poljakov{\'a} and Jan Hraběta and Vojtech Adam and Ren{\'e} Kizek and Emil Frei},
  journal={Current medicinal chemistry},
  year={2012},
  volume={19 25},
  pages={
          4218-38
        }
}
Histone deacetylase (HDAC) inhibitors are a group of anticancer drugs which cause growth arrest and apoptosis of several tumor cells. HDAC inhibitors have been also found to increase the anticancer efficacy of several treatment modalities i.e. chemotherapy or radiotherapy. Here, we review the literature on combinations of HDAC inhibitors both with ionizing radiation and with other drugs, highlighting DNA-damaging compounds. The results of numerous studies with several types of cancer cells… CONTINUE READING