Corpus ID: 14023474

The synergistic anti-neoplastic activity of combinations of mitomycins with either 6-thioguanine or 5-fluorouracil.

@article{Sartorelli1965TheSA,
  title={The synergistic anti-neoplastic activity of combinations of mitomycins with either 6-thioguanine or 5-fluorouracil.},
  author={A. Sartorelli and B. Booth},
  journal={Cancer research},
  year={1965},
  volume={25 9},
  pages={
          1393-400
        }
}
Summary Mitomycin C or porfiromycin (methyl mitomycin) in combination with either 6-thioguanine or 5-fluorouracil produced synergistic inhibition of the growth of both Sarcoma 180 and Lymphoma L1210 ascites cell neoplasms. Mitomycin C and porfiromy cin possessed the same therapeutic index in the L1210 lymphoma system, but mitomycin C was about 5 times more potent. Doses of mitomycin C that induced pronounced inhibition of thymidine- 3 H incorporation into deoxyribonucleic acid (DNA) did not… Expand
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