The syndrome of normal-pressure hydrocephalus.

@article{Vassilouthis1984TheSO,
  title={The syndrome of normal-pressure hydrocephalus.},
  author={John Vassilouthis},
  journal={Journal of neurosurgery},
  year={1984},
  volume={61 3},
  pages={
          501-9
        }
}
A series of 40 patients with the syndrome of normal-pressure hydrocephalus is presented. Diagnosis was based on clinical and computerized tomography (CT) scan criteria and was followed by the insertion of a ventriculoperitoneal shunt in every instance. All patients responded favorably to treatment (four of them had a fair outcome), and this response was maintained. There was one postoperative death, but no other serious complications. This study demonstrates that it is possible to diagnose the… 
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94 Citations
Background Citations
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Methods Citations
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94 Citations

Citation Type

Citation Type

Normal-Pressure Hydrocephalus: An Update
TLDR
The author reviews the evolving understanding of the pathophysiology, diagnosis, and treatment of normal-pressure hydrocephalus and offers a strategy to assist in deciding which patients might benefit from shunting.
Clinical aspects and biology of normal pressure hydrocephalus.
Relationship of new-onset systemic hypertension and normal pressure hydrocephalus.
TLDR
It is suggested that demonstration of new-onset systemic hypertension may also be a clinical sign suggestive of NPH useful in the evaluation of the TBI patient.
Idiopathic normal pressure hydrocephalus associated with empty sella
TLDR
A 70-year-old female presented with the clinical triad of normal pressure hydrocephalus (NPH) and senile tremor and a ventriculoperitoneal shunt did not modify the clinical course except for a mild and transient improvement, and shunt malfunction occurred later on.
Binswanger's disease and normal-pressure hydrocephalus. Clinical and neuropsychological comparison.
TLDR
The patients with normal-pressure hydrocephalus had a later age and more frequent gait disturbance at the onset, shorter duration of the illness, rare signs of vascular disturbances, and more frequently severe mental deterioration.
Shunting normal pressure hydrocephalus: the predictive value of combined clinical and CT data.
TLDR
The study illustrates the need to assess the pre-test probability of NPH based on combined clinical and CT data, before establishing the clinical usefulness of an ancillary test, with patients shunted for presumed normal pressure hydrocephalus.
Cerebrospinal fluid shunting in idiopathic normal-pressure hydrocephalus of the elderly: effect of periventricular and deep white matter lesions.
TLDR
After careful preoperative selection of patients with idiopathic normal-pressure hydrocephalus, individuals with DWMLs suggestive of concomitant vascular encephalopathy may also benefit from cerebrospinal fluid diversion.
Signs, Symptoms and Course of Normal Pressure Hydrocephalus in Comparison with Cerebral Atrophy
TLDR
Subdivision of NPH into an early stage and a late stage allows one to conclude prognostic evaluations about the course of the disease and the complete Adams triad should not be overestimated in differential diagnostic considerations.
Cognitive Recovery in Idiopathic Normal Pressure Hydrocephalus
TLDR
A clear postshunting improvement was seen in 96% of the patients at 1 year with a statistically significant correlation between high wave relative frequency and the grade of improvement (P < 0.05), and 66.6% of shunted patients showed a significant improvement in cognitive functions.
Chapter 60 – Hydrocephalus
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References

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Analysis of 25 patients who fulfilled clinical and radiographic criteria for the diagnosis of "normal pressure" hydrocephalus (NPH) demonstrated (1) a significant relationship between presence of…
Diagnosis of normal-pressure hydrocephalus.
TLDR
From the combination of tests, cases with obstructive-communicating hydrocephalus can be defined for consideration for ventricular-shunt procedures.
Normal pressure hydrocephalus: a histologic study.
TLDR
Although the cause of the meningeal fibrosis, subependymal gliosis, and changes in the arachnoid villae was not clear, these changes could be secondary to an unrecognized previous meningitis.
Normal pressure hydrocephalus and hypertensive cerebrovascular disease.
This report compares the clinical and post mortem findings in a case of normal pressure hydrocephalus (NPH) syndrome occurring in association with hypertensive cerebrovascular disease, with the only…
The clinical effect of lumbar puncture in normal pressure hydrocephalus.
TLDR
The CSF-TT seems to be of value when selecting those patients who will probably benefit from a shunt operation, as normal pressure hydrocephalus patients showed temporary improvement after lumbar puncture.
Normal-pressure hydrocephalus. Predicting the results of cerebrospinal fluid shunting.
TLDR
No significant association was found between the results of shunting and preoperative clinical factors, pneumoencephalography, isotope cisternography, saline infusion tests, or various combinations of clinical and laboratory abnormalities.
Radiological diagnosis of occult normal-pressure hydrocephalus.
TLDR
Cerebral angiography in patients with NPH shows findings characteristic of obstructive hydrocephalus, and early and persistent radioactivity in the ventricles and failure of isotope concentration in parasagittal areas was seen.
Idiopathic normal-pressure hydrocephalus. Results of shunting in 62 patients.
  • P. Black
  • Medicine
    Journal of neurosurgery
  • 1980
TLDR
The data suggest that continued investigation for better predictions of shunt response is important, but that in the meantime the clinical pattern and cranial CT pattern are the most satisfactory guides to improvement after shunting.
Reappraisal of the adult occult hydrocephalus syndrome
TLDR
It is suggested that the excellent results of ventricular shunting are seen primarily in posterior fossa obstruction with lesions involving the aqueduct directly or indirectly.
Predicting the results of cerebrospinal fluid shunting
TLDR
No significant association was found between the results of shunting and preoperative clinical factors, pneumoencephalography, isotope cisternography, saline infusion tests, or various combinations of clinical and laboratory abnormalities.
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