The synaptic vesicle cycle.

  title={The synaptic vesicle cycle.},
  author={Thomas C. Sudhof},
  journal={Annual review of neuroscience},
  • T. Sudhof
  • Published 2004
  • Biology
  • Annual review of neuroscience
Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release, synaptic vesicles undergo a trafficking cycle. The focal point of the vesicle cycle is Ca2+-triggered exocytosis that is followed by different routes of endocytosis and recycling. Recycling then leads to the docking and priming of the vesicles for another round of exo- and endocytosis. Recent studies have led to a better… 

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