The synaptic proteome

@article{Laek2014TheSP,
  title={The synaptic proteome},
  author={Melanie La\ssek and Jens Weingarten and Walter Volknandt},
  journal={Cell and Tissue Research},
  year={2014},
  volume={359},
  pages={255-265}
}
Synapses are focal hot spots for signal transduction and plasticity in the brain. A synapse comprises an axon terminus, the presynapse, the synaptic cleft containing extracellular matrix proteins as well as adhesion molecules, and the postsynaptic density as target structure for chemical signaling. The proteomes of the presynaptic and postsynaptic active zones control neurotransmitter release and perception. These tasks demand short- and long-term structural and functional dynamics of the… CONTINUE READING

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