The synaptic proteins β-neurexin and neuroligin synergize with extracellular matrix-binding vascular endothelial growth factor a during zebrafish vascular development.

@article{Rissone2012TheSP,
  title={The synaptic proteins β-neurexin and neuroligin synergize with extracellular matrix-binding vascular endothelial growth factor a during zebrafish vascular development.},
  author={Alberto Rissone and Efrem Alessandro Foglia and Lorenzo Sangiorgio and Solei Cermenati and Stefania Nicoli and Simona Cimbro and Monica Beltrame and Federico Bussolino and Franco Cotelli and Marco Arese},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2012},
  volume={32 7},
  pages={1563-72}
}
OBJECTIVE The goal of this study was to determine the in vivo functions of the synaptic proteins neurexins and neuroligins in embryonic vascular system development using zebrafish as animal model. METHODS AND RESULTS In the present study, we show that the knockdown of the α-form of neurexin 1a induces balance defects and reduced locomotory activity, whereas β-neurexin 1a and neuroligin 1 morphants present defects in sprouting angiogenesis and vascular remodeling, in particular in the caudal… CONTINUE READING