The synaptic pathology of drug addiction.

  title={The synaptic pathology of drug addiction.},
  author={Michel C van den Oever and Sabine Spijker and August B. Smit},
  journal={Advances in experimental medicine and biology},
A hallmark of drug addiction is the uncontrollable desire to consume drugs at the expense of severe negative consequences. Moreover, addicts that successfully refrain from drug use have a high vulnerability to relapse even after months or years of abstinence. In this chapter, we will discuss the current understanding of drug-induced neuroplasticity within the mesocorticolimbic brain system that contributes to the development of addiction and the persistence of relapse to drug seeking. I… CONTINUE READING
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