The synaptic form of acetylcholinesterase binds to cell-surface heparan sulfate proteoglycans.


We have previously communicated that heparan sulfate and heparin released 16S acetylcholinesterase (AChE) from cholinergic synapses. These experiments suggest that heparan-like molecules are involved in the anchorage of AChE to the neuromuscular junction. In order to prove the in vivo interaction between the 16S AChE and heparan sulfate residues, the… (More)


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