The synapse: from electrical to chemical transmission.

  title={The synapse: from electrical to chemical transmission.},
  author={John Eccles},
  journal={Annual review of neuroscience},
  • John Eccles
  • Published 1982 in Annual review of neuroscience
The controversy as to whether synaptic transmission in the central nervous system is electrical or chemical played a key role in the origin of modern neuroscience, and I shall attempt to give it a historical perspective. Almost 100 years ago (1886--1890) it was recognized by several neuroanatomists, including His, Ford, and Ram6n y Cajal, that nerve cells or neurons were independent biological units and were not mere nodes in the complex net-like structure that was proposed in the reticular… CONTINUE READING