The sympathetic nervous system stimulates anti-inflammatory B cells in collagen-type II-induced arthritis

@article{Pongratz2012TheSN,
  title={The sympathetic nervous system stimulates anti-inflammatory B cells in collagen-type II-induced arthritis},
  author={G. Pongratz and M. Melzer and R. Straub},
  journal={Annals of the Rheumatic Diseases},
  year={2012},
  volume={71},
  pages={432 - 439}
}
  • G. Pongratz, M. Melzer, R. Straub
  • Published 2012
  • Medicine
  • Annals of the Rheumatic Diseases
  • Background As previously shown, the sympathetic nervous system (SNS) shows proinflammatory activity during initiation of arthritis but is anti-inflammatory in established collagen-induced arthritis (CIA). Interleukin 10 (IL-10)-producing B cells suppress arthritis and are a potential target of the SNS because (1) B cells express functional β2-adrenoceptors (β2ARs) and (2) IL-10, at least in monocytes/macrophages, is regulated in a cAMP/PKA/CREB-dependent manner. Objective To test the hypothesis… CONTINUE READING
    The sympathetic nervous response in inflammation
    118

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 22 REFERENCES
    Interleukin‐10: new perspectives on an old cytokine
    796