The sympathetic nervous system stimulates anti-inflammatory B cells in collagen-type II-induced arthritis.

@article{Pongratz2012TheSN,
  title={The sympathetic nervous system stimulates anti-inflammatory B cells in collagen-type II-induced arthritis.},
  author={Georg Pongratz and Madlen Melzer and Rainer H Straub},
  journal={Annals of the rheumatic diseases},
  year={2012},
  volume={71 3},
  pages={432-9}
}
BACKGROUND As previously shown, the sympathetic nervous system (SNS) shows proinflammatory activity during initiation of arthritis but is anti-inflammatory in established collagen-induced arthritis (CIA). Interleukin 10 (IL-10)-producing B cells suppress arthritis and are a potential target of the SNS because (1) B cells express functional β(2)-adrenoceptors (β(2)ARs) and (2) IL-10, at least in monocytes/macrophages, is regulated in a cAMP/PKA/CREB-dependent manner. OBJECTIVE To test the… CONTINUE READING
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